About BioGenex

BioGenex provides a “Total Solution” for slide-based cell and tissue analysis to accelerate clinical diagnostics and drug discovery development. We have developed the total walk-away, industrial-scale automated systems to streamline and standardize an array of processes for cell and tissue testing in immunohistochemistry (IHC), in situ hybridization (ISH), Fluorescent in situ hybridization (FISH), special stains.

Our products include more than 400 antibodies (monoclonal and polyclonal) for various cancer panels, highly sensitive detection kits, automated systems, mRNA, miRNA, and FISH probes, ancillary reagents, and consumables. We accommodate diverse laboratory needs with an array of clinical and research automation platforms that meet global quality standards (ISO 13485 & ISO 9001), are approved by the FDA and CE-marked. BioGenex is a global market leader in molecular pathology providing customer-centric solutions for complete automation of cell and tissue staining. Through its cutting-edge and patented technologies, the company has transformed the practice of slide-based staining in many molecular pathology laboratories.

ISH/CISH

In Situ Hybridization (ISH) is a powerful technique for precise detection and localization of a specific nucleic acid sequence within a histologic section. The underlying principle of ISH is that the nucleic acids within a histologic specimen can be detected by the hybridization of a complementary nucleic acid probe in which a reporter molecule is attached. Common non-radioactive labels for probe are fluorescein and digoxigenin. Subsequent visualization of the reporter molecule localizes DNA or RNA sequences in tissue or cells samples.

There are two basic approaches to visualize the DNA or RNA target sequences in situ: chromogenic in situ hybridization (CISH) and fluorescence in situ hybridization (FISH). While these approaches involve the same underlying principle, the instrumentation required to visualize the specimen is different.

ISH has broad applications such as physical chromosome mapping, karyotyping, and pathogen profiling. Riboprobes also enables the localization and analysis of gene expression profile.

Quick Inquiry Form